National University of Ireland, Maynooth

National University of Ireland, Maynooth
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Faculties & Departments

Department of Biology

Head of Laboratory:  Professor John Findlay, BSc (Aberdeen), PhD (Leeds),

 

The Marie Curie Laboratory for Membrane Proteins

Marie Curie Laboratory for Membrane Proteins

Left to right:  John Findlay, with two Marie Curie Fellows, Lisa Tang and Werner Vos at the opening of the Laboratory.

General Research Interests

Biological membranes are the point of contact between living cells and the environment, and the proteins embedded in them mediate a wide range of processes including nutrient transport, and the signaling actions of hormones and drugs. The techniques needed to investigate membrane proteins are hugely important for investigations ranging from fundamental studies on structure and cellular biology, to exciting humanitarian and commercial applications in arenas such as drug discovery and delivery, and the emergent field of biosensors. The laboratory is dedicated to the application of these techniques in the study of a range of systems important to human biology.

Specific projects

At present, two principal areas are the main focus of attention. These are the receptor for Retinol Binding Protein (RBP) which has been a central interest for at least two decades and which has recently received a huge boost by the identification of the corresponding gene. Current work is involved with understanding the structure/function relationships of a number of facets of the mechanism of action of this receptor-the binding of extracellular and intracellular RBPs, the transport of retinol and interactions with other proteins and systems. A chemical biology approach is being taken to probe the functional behaviour of the protein particularly in the context of diseases such as derangements in tissue development and type 2 diabetes.

Retinol Binding Protein

The second research area, also a long-standing interest, is G-protein coupled receptors (GPCRs). Here, activity is concerned with the design and discovery of new agonists/antagonists and pharmacological chaperones, with the characterization and “de-orphanising” of members of new distinct families of GPCRs and with the use of these receptors in a new format for biosensors.

GPCRs

Further projects on-going in the laboratory can be found under the entries for Drs. Gemma Kinsella and Werner Vos.

Current Laboratory Members

Group Photo

Back row (Left to right): Dr.Werner Vos, Prof John Findlay, Dave Cooney, Dr. Conor Breen, Dr. Akos Pal, Dr. Darren Martin & Dr. Jose Angel Campos Sandoval. Front Row (Left to right): Pamela Young, Dr. Gemma Kinsella, Kate McQuaid, Dr. Julia Hinderberger & Dr. Victoria McEneaney

Funding Sources

The laboratory of Membrane Proteins was set up with an award from the EC (TOK with Profs. P. Dix and J. Findlay as supervisors) and a grant-in-aid from NUI Maynooth. Since then, further research income has been obtained from Enterprise Ireland, Science Foundation Ireland and the European Commission (IAPP) in the areas outlined. In addition independent fellows have joined the Laboratory with funding provided by IRCSET and the Health Research Board.

Recent Publications

  • Wysocka-Kapcinska M, Sandoval JA, Pal A, Findlay JBC. Expression and characterization of recombinant human retinol-binding protein in Pichia pastoris. Protein Expr Purif. (2010) In Press
  • Vos WL, Vaughan S, Lall PY, McCaffrey JG, Wysocka-Kapcinska M, Findlay JBC Expression and structural characterization of peripherin/RDS, a membrane protein implicated in photoreceptor outer segment morphology. Eur. Biophys. J. (2010) In Press
  • Ansell RJ, Tunon PG, Wang Y, Myers P, Ivory CF, Keen JN, Findlay JBC 'Electophoretic field gradient focusing with on-column detection by fluorescence quenching ' ROYAL SOCIETY OF CHEMISTRY: ANALYST 134 pp 226-229 (2009)
  • Sanderson JM, Singh P, Fishwick CEG, et al. 'The synthesis and reactivity of optically pure amino acids bearing side-chain thiomides' JOURNAL OF CHEMISTRY SOCIETY PERKIN TRANSACTIONS 1 pp 3227-3231 (2009)
  • Gage M.C., Keen, J.N., Buxton, A.T., Bedi, M.K. and Findlay, J.B.C  Proteomic Analysis of IgE-Mediated Secretion by LAD2 Mast Cells.  J. Proteome Res., DOI: 10.1021/pr900108w, e-pub (2009).
  • Richard J Bingham, John BC Findlay, Shih-Yang Hsieh, Arnout P Kalverda, Alexandra Kjellberg, Chiara Perazzolo, Simon E V Phillips, Kothandaraman Seshadri, Chi H Trinh, W. Bruce Turnbull, Geoffrey Bodenhausen and Steve W Homans 'Thermodynamics of Binding of 2-methoxy-3-isopropylpyrazine and 2-methoxy-3-isobutylpyrazine to the Major Urinary Protein' JOURNAL OF AMERICAN CHEMISTRY SOCIETY 126 pp 1675-1681 (2008)
  • Kota, Zoltan, Pali, Tibor, Dixon, Neil, Kee, Terry P., Harrison, Michael A., Findlay, John B. C., Finbow, Malcolm E., Marsh, Derek. 'Incorporation of transmembrane peptides from the vacuolar H+-ATPase in phospholipid membranes: Spin-label electron paramagnetic resonance and polarized infrared spectroscopy.' BIOCHEMISTRY 47 pp 3937-3949 (2008)
  • Dixon et al 'Interaction of spin-labelled inhibitors of the Vacuolar ATPase with the transmembrane sector.' BIOPHYSICAL JOURNAL 94 pp 506-514 (2008)
  • Redondo C, Vouropoulou M, Evans J and Findlay JBC 'The identification of the Retinol Binding Protein interaction site and functional state of RBPs for the membrane receptor.' FASEB JOURNAL 22 pp 1043-1054 (2008)
  • Xia XB, Postis VLG, Rahman M, Wright GSA, Roach PCJ, Deacon SE, Ingram JC, Henderson PJF, Findlay JBC, Phillips SEV. 'Investigation of the structure and function of a Shewanella oneidensis arsenical-resistance family transporter.' MOLECULAR MEMBRANE BIOLOGY 25 (2008)
  • Jean Breton, Matthew C Gage, Alastair W Hay, Jeffrey N Keen, Christopher P Wild, Clare Donnellan, John B C Findlay and Laura J Hardie. 'Proteomic Screening of a Cell Line Model of Esophageal Carcinogenesis Identifies Cathepsin D and Aldo-Keto Reductase 1C2 and 1B10 Dysregulation in Barrett?s Esophagus and Esophageal Adenocarcinoma.' JOURNAL OF PROTEOME RESEARCH 7 pp 1953-1962 (2008)
  • Duarte, A.M., C.J. Wolfs, N.A. van Nuland, M.A. Harrison, J.B. Findlay, C.P. van Mierlo and M.A. Hemminga 'Structure and localization of an essential transmembrane segment of the proton translocation channel of yeast H+-VATPase' BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1768 (2007)
  • Clare DK, Orlova EV, Finbow MA, et al. '  An expanded and flexible form of the vacuolar ATPase membrane sector.' STRUCTURE 14 pp 1149-1156 (2006)
  • Findlay JBC. 'COST D22. Protein-lipid interactions: the membrane dimension.' CHEMISTRY AND PHYSICS OF LIPIDS 141 (2006)
  • Redondo,C. Burke,B. and Findlay.J.B.C. 'The Retinal Binding Protein system: A Potential Paradigm for Steroid Binding Globulins' HORMONE AND METABOLIC RESEARCH 28 pp 269-278 (2006)
  • Eleanor M Scott, Angela M Carter, John B C Findlay. 'The application of proteomics to diabetes' DIABETES & VASCULAR DISEASE RESEARCH 2 pp 54-60 (2005)
  • Sanderson JA, Findlay JBC, Fishwick CWG. 'Preparation of novel 3H-trifluoromethyldiazirine-based photoactivatable potassium channel antagonists.' TETRAHEDRON 61 pp 11244-11252 (2005)
  • Ali MA, Bhogal N, Findlay JBC, et al 'The first de novo-designed antagonists of the human NK2 receptor' JOURNAL OF MEDICINAL CHEMISTRY 48 pp 5655-5658 (2005)
  • Ali MA, Bhogal N, Findlay JBC, et al 'The first de novo-designed antagonists of the human NK2 receptor' JOURNAL OF MEDICINAL CHEMISTRY 48 pp 5655-5658 (2005)
  • Graham Whyteside, Peter J Meek, Steven K Ball, Neil Dixon, Malcolm E Finbow, Terence P Kee, John B C Findlay and Michael A Harrison. 'Concanamycin and Indolyl Pentadieneamide Inhibitors of the Vacuolar H+-ATPase Bind with High Affinity to the Purified Proteolipid Subunit of the V0 Membrane Domain.' BIOCHEMISTRY 44 pp 15024-15031 (2005)
  • Alan Cox, Dan Donnelly, Manminder Kaur, Sharon C Cheetham, Victor B Cockroft, John BC Findlay 'MTSEA prevents ligand binding to the human melanocortin-4 receptor by modification of cysteine 130 in transmembrane helix 3.' FEBS LETTERS 579 pp 285-292 (2005)
  • Weiss,JL, Evans,NA, Ahmed,T, Wrigley,JDJ, Khan,S, Wright,C, Keen,J, Holzenburg,A, and Findlay, JBC, 'Methionine-rich repeat proteins:a family of membrane-associated proteins which contain unusual repeats' BIOCHIMICA ET BIOPHYSICA ACTA 1668 pp 167-174 (2005)
  • Blades MJ, Ison JC, Ranasinghe R, Findlay JBC. 'Automatic generation and evaluation of sparse protein signatures for families of protein structural domains' PROTEIN SCIENCE 14 pp 13-23 (2005)
  • Richard P O Jones, Lyndsey J Durose, John B C Findlay and Michael A Harrison 'Defined Sites of Interaction between Subunits E (Vma4p), C (Vma5p), and G (Vma10p) within the Stator Structure of the Vacuolar H+-ATPase' BIOCHEMISTRY 44 pp 3933-3941 (2005)
  • Strudwick N, Bhogal N, Evans NA, Blaney FE, Findlay JBC. 'Evidence to support a spectrum of active states for the glucagon receptor' BIOCHEMICAL SOCIETY TRANSACTIONS 32 pp 1037-1039 (2004)
  • Howes JM, Keen JN, Findlay JBC, Grant PJ, Carter AM. 'Deciphering the plasma clot Proteome' MOLECULAR & CELLULAR PROTEOMICS 3 (2004)
  • Keen JN, Bedi MK, Findlay JBC. 'Preparation and analysis of a low molecular weight human plasma proteome.' MOLECULAR & CELLULAR PROTEOMICS 3 (2004)
  • Gage MC, Keen JN, D?Amato A, Buxton AT, Findlay JBC 'The proteomics of mast cell secretion.' MOLECULAR & CELLULAR PROTEOMICS 3 (2004)
  • Tibor Pa´li, Graham Whyteside, Neil Dixon, Terence P. Kee, Stephen Ball, Michael A. Harrison, John B. C. Findlay, Malcolm E. Finbow, and Derek Marsh. 'Interaction of Inhibitors of the Vacuolar H+-ATPase with the Transmembrane Vo-Sector?' BIOCHEMISTRY 43 pp 12297-12305 (2004)
  • de Maturana RL, Treece-Birch J, Abidi F, Findlay JBC, Donnelly D. 'Met-204 and Tyr-205 are together important for binding GLP-1 receptor agonists but not their N-terminally truncated analogues' PROTEIN AND PEPTIDE LETTERS 11 pp 15-22 (2004)
  • Bhogal N, Blaney FE, Ingley PM, Rees and Findlay JBC 'The proximity of the extreme N-terminus of the NK2 tachykinin receptro to Cys167 in the putative fourth transmembrane helix' BIOCHEMISTRY 43 pp 3027-3038 (2004)
  • Tibor Pa´li, Graham Whyteside, Neil Dixon, Terence P. Kee, Stephen Ball, Michael A. Harrison, John B. C. Findlay, Malcolm E. Finbow, and Derek Marsh. 'Interaction of Inhibitors of the Vacuolar H+-ATPase with the Transmembrane Vo-Sector?' BIOCHEMISTRY 43 pp 12297-12305 (2004)
  • Bhogal N, Blaney FE, Ingley PM, Rees and Findlay JBC 'The proximity of the extreme N-terminus of the NK2 tachykinin receptro to Cys167 in the putative fourth transmembrane helix' BIOCHEMISTRY 43 pp 3027-3038 (2004)
  • Leach RN, Boyett MR, Findlay JBC 'Expresison, purification and spectroscopic studies of full-length Kir3.1 channel C-terminus' BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 1652 pp 83-90 (2003)
  • Zhang R, Seshadri K, Findlay JBC, Hsieh S-Y, Kalverda A P, Homans S W and Miles Brown J 'Methyl Side Chain Dynamics in Proteins Using Selective Enrichment with a Single Isotopomer' JOURNAL OF AMERICAN CHEMISTRY SOCIETY 125 pp 15767-15771 (2003)
  • Harrison M, Durose L, Song CF, Barratt E, Trinick J, Jones R, Findlay JBC 'Structure and function of the vacuolar H+-ATPase: Moving from low-resolution models to high-resolution structures.' JOURNAL OF BIOENERGETICS AND BIOMEMBRANES 35 pp 337-345 (2003)
  • Cosma Dellisanti, Siliva Spinelli, Christian Cambillau, John B C Findlay, Peter F Zagalsky, Stéphanie Finet, Véronique-Bréchot. 'Quarternary Structure Of Alpha-Crustacyanin From Lobster As Seen By Small Angle X-Ray Scattering.' FEBS LETTERS 244 pp 189-193 (2003)
  • Dixon N, Pali, T, Ball S, et al 'New biophysical probes for structure-activity analyses of vacuolar-H+-ATPase enzymes.' ORGANIC AND BIOMOLECULAR CHEMISTRY 24 pp 4361-4363 (2003)
  • Findlay JBC, Harrison MA 'A protein chemical approach to channel structure and function: the proton channel of the vacuolar H+-ATPase' NOVARTIS FOUNDATION SYMPOSIUM 245 pp 207-222 (2002)
  • Dobrzynski H, Janvier NC, Leach R, et al 'Effects of ACh and adenosine mediated by Kir3.1 and Kir3.4 on ferret ventricular cells' AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PH 283 (2002)
  • M Sundaram, DNF van Aalten, A Sivaprasadarao and JBC Findlay 'The transfer of transthyretin and receptor-binding properties from the plasma retinol-binding protein to the epididymal retinoic acid-binding protein' BIOCHEMICAL JOURNAL 362 pp 265-271 (2002)
  • LV Mello, PA Millner, JBC Findlay. 'Biochemical Charcteristics of Guanine Nucleotide Binding Protein a-Subunit Recombinant Protein and Three Mutants: Investigation of a domain Motion involved in GDP-GTP Exchange.' JOURNAL OF PROTEIN CHEMISTRY 21 pp 29-34 (2002)
  • Jonathan DJ Wrigley, Claire L Nevett, and John BC Findlay. 'Topological analysis of peripherin/rds & abnormal glycosylation of the pathogenic P216L mutation' BIOCHEMICAL JOURNAL 368 pp 649-655 (2002)
  • Barratt EA, Thompson GS, Harrison MA, Homans SW, Findlay JBC 'Structural analysis of Vma7p, subunit F of the vacuolar H+ATPase' BIOPHYSICAL JOURNAL 82 pp 2218 (2002)
  • Labrou NE, Bhogal N, Hurrell CR, Findlay JBC. 'Interaction of Met (297) in the seventh transmembrane segment of the tachykinin NK2 receptor with neurokinin A.' JOURNAL OF BIOLOGICAL CHEMISTRY 276 pp 37944-37949 (2001)
  • Richard PO Jones, Ian E Hunt, Joachin Jaeger, Alison Ward, John O'Reilly, Elizabeth A Barratt, John BC Findlay & Michael A Harrison. 'Expression, purification and secondary structure analysis of Saccharomyces cerevisiae vacuolar membrane H+-ATPase subunit (Vma7p).' MOLECULAR MEMBRANE BIOLOGY 18 pp 283-290 (2001)
  • Ali MA, Bhogal N, Fishwisk CWG, Findlay JBC 'Spatial requirements of the antagonist binding site of the NK2 receptor.' BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 11 pp 819-822 (2001)
  • Dibb KM, Leach R, Findlay JBC, et al 'A glutamate residue GIRK4-E145 in the H5 pore region of GIRK1/GIRK4 affects channel characteristics.' BIOPHYSICAL JOURNAL 80 (2001)
  • Ison JC, Parish JH, Daniel SC, Blades MJ, Bleasby AJ & Findlay JBC. 'Key Residues Approach to the Definition of Protein Families and Analysis of Sparse Family Signatures' PROTEINS: STRUCTURE, FUNCTION & GENETICS 40 pp 330-341 (2000)
  • Lancaster MK, Dibb KM, Leach R, et al 'Slow activation of the cardiac muscarinic K+ channel Kir3.1-Kir3.4 is due to polymines unbinding from charged sites within the channel pore.' JOURNAL OF PHYSIOLOGY-LONDON 527 (2000)
  • Leach RN, Lancaster MK, Boyett MR, et al 'Direct binding of polyamines by Kir channel proteins.' JOURNAL OF PHYSIOLOGY-LONDON 527 (2000)
  • Dibb KM, Leach R, Quinn CC, et al 'Glutamate residues in the H5 pore region of GIRK1-GIRK4 control Ba2+ block.' JOURNAL OF PHYSIOLOGY-LONDON 527 (2000)
  • Dibb KM, Leach R, Lancaster MK, et al 'Cs+ block of the cardiac muscarinic K+ channel, GIRK1/GIRK4, is not dependent on the asparate residue at position 173.' PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 440 pp 740-744 (2000)
  • Matthew K Lancaster, Katherine M Dibb, Claire C Quinn, Robert Leach, Jong-Kook Lee, John BC Findlay, Mark R Boyett. 'Residues and Mechanisms for Slow Action and Ba2+ Block of the Cardiac Muscarinic K+ Channel, Kir3.1/Kir3.4.' JOURNAL OF BIOLOGICAL CHEMISTRY 275 pp 35831-35839 (2000)
  • Michael Harrison, Ben Powell, Malcolm E Finbow, John BC Findlay. 'Identification of Lipid-Accessible Sites on the Nephrops 16-kDa Proteolipid Incorporated into a Hybrid H+-ATPase: Site-Directed Labeling with N-(1-Pyrenyl)cyclohexylcarbodiimide and Fluorescence Quencing Analysis' BIOCHEMISTRY 39 pp 7531-7537 (2000)
  • Carlos AO Ricart, Alan Wise, John BC Findlay, Paul A Milner. 'Presence of Rhodopsin-like Proteins in Sorghum bicolor and Pisum sativum.' JOURNAL OF PLANT PHYSIOLOGY 156 pp 300-305 (2000)
  • Leach RN, Lancaster MK, Boyett MR, Findlay JBC 'Evidence for direct binding of polymines to Kir3.1/Kir3.4 channel proteins.' BIOPHYSICAL JOURNAL 78 (2000)
  • Lancaster MK, Dibb KM, Leach R, Findlay JBC, Boyett MR. 'Multiple residues are involved in the slow activation of the cardiac muscarinic K+ channel' BIOPHYSICAL JOURNAL 78 (2000)
  • Wrigley JDJ, Ahmed T, Nevett CL, Findlay JBC 'Peripherin/rds influences membrane vesicle morphology' JOURNAL OF BIOLOGICAL CHEMISTRY 275 pp 13191-13194 (2000)
  • Dibb KM, Leach R, Lancaster MK, et al 'Cs+ block of the cardiac muscarinic K+ channel, GIRK1/GIRK4, is not dependent on the asparate residue at position 173.' PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY 440 pp 740-744 (2000)
  • Lancaster MK, Dibb KM, Leach R, Findlay JBC, Boyett MR. 'Multiple residues are involved in the slow activation of the cardiac muscarinic K+ channel' BIOPHYSICAL JOURNAL 78 (2000)
  • 3. Chau PL, van Aalten DMF, Bywater RP and Findlay JBC 'Functional concerted motions in the bovine serum retinol-binding protein.' JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN 13 pp 11-20 (1999)
  • Dibb KM, Leach R, and Lancaster MK. 'Block of the cardiac muscarinic K+ channel Kir3.1/Kir3.4 by flufeamic acid.' BRITISH JOURNAL OF PHARMACOLOGY 128 (1999)
  • Findlay JBC 'Mapping of the ligand binding domain of the human tachykinin NK2 receptor.' BRITISH JOURNAL OF PHARMACOLOGY 128 (1999)
  • Lott JS, Carne A, Evans N, Findlay JBC 'The ordered visual transduction complex of the squid photreceptor membrane' MOLECULAR NEUROBIOLOGY 20 pp 61-80 (1999)
  • Daniel SC, Parish JH, Ison JC, Blades MJ, Findlay JBC 'Alignment of a sparse protein signature with protein sequences: application to fold prediction for three small globulins' FEBS LETTERS 459 pp 349-352 (1999)
  • Bentley GN, Brooks MA, O?Neill CA, Findlay JBC 'Determinants of potassium channel assembly localised within the cytoplasmic C-terminal domain of Kv2.1' BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1418 pp 176-184 (1999)
  • Owen JM, Quinn CC, Leach R, Findlay JBC, Boyett MR. 'Effect of extracellular cations on the inward rectifying K+ channels Kir2.1 and Kir3.1/Kir3.4' EXPERIMENTAL PHYSIOLOGY 84 pp 471-488 (1999)
  • Harrison MA, Murray J, Powell B, Yong-In K, Finbow M E, Findlay JBC. 'Helical Interactions and Membrane Disposition of the 16-kDa Proteolipid Subunit of the Vacuolar H+-ATPase Analysed by Cysteine Replacement Mutagenesis' JOURNAL OF BIOLOGICAL CHEMISTRY 274 pp 25461-25470 (1999)
  • al Jandal N, Farrar GJ, Kiang AS, Humphries MM, Bannon N, Findlay JBC, Humphries P, and Kenna PF 'A novel mutation without the rhodopsin gene (Thr-94-Ile) causing autosomal dominant congenital stationary night blindness' HUMAN MUTATION 13 pp 75-81 (1999)
  • Degtyarenko KN, North ACT and Findlay JBC 'PROMISE: a database of bioinorganic motifs' NUCLEIC ACIDS RESEARCH 27 pp 233-236 (1999)
  • Mello LV, vanAlten DME and Findlay JBC 'Dynamic properties of the guanine nucleotide binding protein alpha subunit and comparison of its guanosine triphosphate hydrolase domain with that of ras p21' BIOCHEMISTRY 37 pp 3137-3412 (1999)
  • Findlay JBC 'Mapping of the ligand binding domain of the human tachykinin NK2 receptor.' BRITISH JOURNAL OF PHARMACOLOGY 128 (1999)
  • Labrou NE, Mello LV, Rigden DJ, Keen JN, Findlay JBC. 'Structure-activity studies on cysteine-substituted neurokinin A analogs' PEPTIDES 20 pp 795-801 (1999)
  • Donnelly D, Maudsley S, Gent JP, Moser RN, Hurrell CR and Findlay JBC 'Conserved polar residues in the transmembrane domain of the human tachykinin NK2 receptor: functional roles and structural implications' BIOCHEMICAL JOURNAL 339 pp 55-61 (1999)
  • Maudsley S, Gent JP, Findlay JBC and Donnelly D 'The relationship between the agonist-induced activation and desensitisation of the human tachykinin NK2 receptor expressed in Xenopus oocytes.' BRITISH JOURNAL OF PHARMACOLOGY 124 pp 675-684 (1998)
  • van Aalten DMF, Hoff WD, Findlay JBC, Crielaard W and Hellingwerf KJ 'Concerted motions in the photoactive yellow protein' PROTEIN ENGINEERING 11 pp 873-879 (1998)
  • Sundaram M, Sivaprasadarao A, van Aalten DMF and Findlay JBC 'Expression, characterisation and engineered specificity of rat epididymal retinoic acid-binding protein' BIOCHEMICAL JOURNAL 334 pp 155-160 (1998)
  • Aggeli A, Bannister ML, Boden N, Findlay JBC, Hunter M, Knowles PF and Yang J-C 'Conformation and ion-channelling activity of a 27-residue peptide modelled on the single-transmembrane segment of the IsK (minK) protein' BIOCHEMISTRY 37 pp 8121-8131 (1998)
  • Degtyarenko KN, North ACTN, Perkins DN and Findlay JBC 'PROMISE: a database information on prosthetic centres and metal ions in protein active sites.' NUCLEIC ACIDS RESEARCH 26 pp 376-381 (1998)
  • Sundaram M, Sivaprasadarao A, De Sousa MM and Findlay JBC 'The transfer of retinol from serum retinol-binding protein to cellular retinol binding protein is mediated by a membrane receptor' JOURNAL OF BIOLOGICAL CHEMISTRY 273 pp 3336-3342 (1998)
  • Murray JG, Powell B, Harrison MA and Findlay JBC 'Structure and function of the 16-kDa proteolipid of the yeast vacuolar H+ATPase' ACTA PHYSIOLOGICA SCANDINAVICA 163 pp 311-311 (1998)
  • Cox A, Law NM and Findlay JBC 'Inhibition of cromolyn-induced phosphorylation of a 78 kDa protein by phorbol esters in rat peritoneal mast cells.' BIOCHEMICAL PHARMACOLOGY 55 pp 585-594 (1997)
  • Singh P, Hurrell CR, Findlay JBC and Fishwick CWG 'Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides.' BIOORGANIC & MEDICINAL CHEMISTRY 7 pp 715-718 (1997)
  • Leach R, Quinn C, Owen JM, Findlay JBC and Boyett MR. 'A 'rectification residue' in the pore region of the cardiac muscarinic K+ channel, GIRK1-CIR' JOURNAL OF PHYSIOLOGY 499 pp 130-130 (1997)
  • Findlay JBC, Finbow ME, Jones PC, Kim Y-I, Harrison MA and Hughes G 'A structure-based model for the 16 kDa membrane sector of the vacuolar H+-ATPase' BIOCHEMICAL SOCIETY TRANSACTIONS 25 pp 1107-1113 (1997)
  • Owen JM, Hulme JT, Leach R, Findlay JBC, Hopkins P, Boyett MR and Orchard CH 'Comparison of the effects of acidosis on the transient outward K+ current in ferret ventricular myocytes and a cloned transient outward K+ channel, FK1, from ferret ventricle.' JOURNAL OF PHYSIOLOGY 504 pp 77-77 (1997)
  • van Aalten DMF, Conn DA, de Groot BL, Berendsen HJC, Findlay JBC and Amadei A 'Protein dynamics derived from clusters of crystal structures' BIOPHYSICAL JOURNAL 73 pp 2891-2896 (1997)
  • Mello LV, Van Aalten DMF and Findlay JBC 'Comparison of ras-p21 bound to GDP and GTP: Differences in protein and ligand dynamics' PROTEIN ENGINEERING 10 pp 381-387 (1997)
  • Harrison MA, Finbow ME, Findlay JBC 'Postulate for the molecular mechanism of the vacuolar H+-ATPase.' MOLECULAR MEMBRANE BIOLOGY 14 pp 1-3 (1997)
  • Van Aalten DMF, Jones P, De Sousa M, Findlay JBC. 'Engineering protein mechanics: Inhibition of concerted motions of the cellular retinol binding protein by site-directed mutagenesis' PROTEIN ENGINEERING 10 pp 31-37 (1997)
  • Van Aalten DMF, DeGroot BL, Findlay JBC, Berendsen HJV, Amadei A 'A comparison of techniques for calculating protein essential dynamics.' JOURNAL OF COMPUTATIONAL CHEMISTRY 18 pp 169-181 (1997)
  • Leach R, Quinn C, Owen JM, Findlay JBC and Boyett MR 'A 'rectification residue' in the pore (H5) region of the cardiac muscarinic K+ channel, GIRK1-CIR.' BIOPHYSICAL JOURNAL 72 (1997)
  • Singh P, Hurrell CR, Findlay JBC and Fishwick CWG 'Two novel amino acid derivatives containing side-chain thioamides for the synthesis of photoactivatable peptides.' BIOORGANIC & MEDICINAL CHEMISTRY 7 pp 715-718 (1997)
  • Horvath LI, Knowles PF, Kovachev P, Findlay JBC and Marsh DE 'A single-residue deletion alters the lipid selectivity of a K+ channel-associated peptide in the b-conformation: Spin label electron spin resonance studies.' BIOPHYSICAL JOURNAL 73 pp 2588-2594 (1997)
  • Degtyarenko KN, North ACT, Findlay JBC 'Promise: A new database of information on prosthetic centres and metal ions in protein active sites.' PROTEIN ENGINEERING 10 pp 183-186 (1997)

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Last edited: Thursday, 11-Mar-2010 12:29:06 GMT

Biology Department , NUI Maynooth
Tel: +353-1-708 3843 | Fax: +353-1-708 3845| Email: terry.roche@nuim.ie